Tennessee Titans vs Buffalo Bills 9/19/22 Prediction and DraftKings Sportsbook Promo

Last updated September 19, 2022 | Published September 16, 2022

11:15 PM ET Sep 19
Tennessee Titans vs Buffalo Bills
Buffalo Bills -10

The Buffalo Bills (1-0) will host the Tennessee Titans (0-1) for Monday's game at Highmark Stadium in Orchard Park, New York. The last meeting between the two teams was on October 19, 2021, when the Titans got a close 34-31 victory that also took place on Monday Night Football.

For their meeting in Week 2, the Bills are favored to win with a 10-point spread while the Titans are at +10 (-110). You can bet with DraftKings' Bet $5 Get $200 promo for this game, as new users will get $200 in free bets from DraftKings in exchange for a $5 bet, whether that $5 bet wins or loses.

The Pick: The Bills -10 (-110)
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Why bet on the Bills?

✅ The Bills lead the AFC East with 31 points scored per game after Week 1, and did that against the defending Super Bowl champion Rams.
✅ The Bills are seventh in yards gained through one week with 418, led by Josh Allen with 297 yards passing.
✅ The Bills' defense allowed 243 yards and 10 points, which is the second best in the NFL through the first week of the season.

TeamsTennessee Titans vs Buffalo Bills
WhenMonday, September 19, at 7:15 p.m ET
VenueHighmark Stadium, Orchard Park, NY
Betting PickThe Bills to cover | Spread @ -10 (-110)

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Tennessee Titans vs Buffalo Bills

Tennessee Titans

The Titans lost 21-20 to the New York Giants last Sunday. They in control until late in the second half but failed to win the game, with a late missed field goal by Randy Bullock giving them a disappointing loss. Ryan Tannehill threw for 266 yards and two touchdowns and had a passer rating of 106.4 in the recent game against the Giants. While the Titans struggled to get their offense going in Week 1, they still have a chance to beat a Bills team they defeated last season.

The Titans have several names on their injury report from the last game. Jamarco Jones is suffering a tricep injury. Lonnie Johnson Jr. was out of the previous game due to a groin injury. Lastly, Ola Adeniyi missed the previous game due to a shoulder injury.

Buffalo Bills

The Bills had a comfortable 31-10 victory against the reigning champion LA Rams in the first week of the season. The Bills defense became the main attraction. Against the Rams, Greg Rousseau, A.J. Epenesa, and Boogie Basham all took control. Rousseau recorded a sack. He also had two tackles and a pass deflection, while Basham had a sack and an interception for a Bills defense that shut the Rams out in the second half.

However, the Bills have some injury updates of their own. Ed Oliver exited last week's game with an ankle injury. Following Oliver, Tommy Doyle departed from the game with a foot injury. Quintin Morris was also out due to a hamstring injury. The team officials have yet to confirm whether they will be included in Monday's lineup.

Gus Anderson
Gus Anderson is a gambling wizard. As a kid he dreamt about becoming a Tennis, Hockey and Golf professional but ended up as a gambling professional with focus on both sports & casino.