San Diego Padres vs St. Louis Cardinals 9/21/22 Prediction and DraftKings Sportsbook Promo

Last updated September 21, 2022

1:40 AM ET Sep 22
San Diego Padres vs St. Louis Cardinals
San Diego Padres to win

On Wednesday, the San Diego Padres (81-66) are set to face the St. Louis Cardinals (87-61) for the second time after earning the series-opening win (5-0) at PETCO Park. Blake Snell is set to get the start for the Padres in this game against Miles Mikolas for the Cardinals.

The Cardinals were knocked around by the Padres during the opening of their three-game series by a score of 5-0, after coming off a defeat against the Cincinnati Reds by a 3-0 margin. The same day, the favored Padres won their game against the Arizona Diamondbacks by a 6-1 score. They are the moneyline favorites for this upcoming home game at -130, while the Cardinals are the underdog at +110.

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The Pick: San Diego Padres | Moneyline @ -130
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Why bet on the San Diego Padres?

✅ The Padres are riding a four-game winning streak coming into this game and are playing better baseball right now than St. Louis.
✅ The Padres have more to play for in this game as they are still fighting for a playoff spot, while the Cardinals are more or less in the postseason.
✅ The Padres have more quality starts as a team with 77 compared to the Cardinals' 56.

TeamsSan Diego Padres vs St. Louis Cardinals
WhenWednesday, September 21, at 9:00 p.m. ET
VenuePETCO Park in San Diego, CA
Betting PickSan Diego Padres to win Moneyline @ -110

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San Diego Padres vs St. Louis Cardinals

San Diego Padres 

Facing the St. Louis Cardinals on Wednesday for the second time in this series, the San Diego Padres (81–66) hope to keep up their winning streak after earning consecutive victories during their last three games against the Arizona Diamondbacks and against the Cardinals (5-0) during the series opener. The current season standings put the Padres second best in National League West. They are third among the Wild Card teams, making them eligible for the postseason if they can hold onto their current position.

Outfielder Juan Soto was a highlighted player during their last game when he went 3-for-4 with a double, a home run and two RBIs. The matchup then saw third baseman Manny Machado's 29th homer, and pitcher Yu Darvish (15-7, 3.05 ERA) threw six scoreless innings and one hit. Darvish struck out eight and walked one in his fifth straight win.

The official injury report outlines two relief pitchers who are put on a 60-day injury list, which are Austin Adams (forearm) and Drew Pomeranz (elbow) who had to undergo flexor tendon surgery. They are expected to return early next year.

Saint Louis Cardinals 

Before taking a 5-0 loss in the series opener, the St. Louis Cardinals were coming off a defeat over the Cincinnati Reds from their last game by a 3-0 margin. Despite their recent loss, the team is 87-62, putting them first on the National League Central standings with a winning percentage of 0.588.

The Cardinals rank fourth in MLB with 713 runs scored this season. Their batting average is .254. First baseman Paul Goldschmidt leads the team with an on-base percentage of .411, a slugging percentage of .599, and 168 hits, while infielder Brendan Donovan looks to get his 100th hit of the season during the approaching game with the Padres. Miles Mikolas is going to take the mound for the Cardinals in this game as he looks to get to 12-12 on the season with a win here.

The official report places center field Tyler O'Neill and three relief pitchers, Jordan Hicks, Drew Verhagen and Alex Reyes, on the injury list. O'Neill heads for a 10-day break with a left hamstring strain after Saturday's game. Hicks injured his neck on the same day as well. Verhagen (hip) and Reyes (shoulder) undergo a season-ending injury and are put on a 60-day injury list.

Gus Anderson
Gus Anderson is a gambling wizard. As a kid he dreamt about becoming a Tennis, Hockey and Golf professional but ended up as a gambling professional with focus on both sports & casino.