49ers vs Seahawks Sportsbook Promos & Prediction 12/15/22

December 15, 2022

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1:15 AM ET Dec 16
49ers vs Seahawks
Seahawks +3.5
-110
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Week 15 of the NFL season will kick off in Seattle, as the Seattle Seahawks host the San Francisco 49ers. These teams are the only competitors left in the NFC West title race, and the outcome of this game could go a long way in determining who wins the division and hosts a playoff game.

In our NFL betting picks for Week 15, we look at this 49ers vs Seahawks matchup, and look at the best sports betting promos for the game as well.

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The Pick: Seahawks +3.5
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Why bet on the Seahawks:

✅ We are going to see a very different version of the 49ers offense than we have in the last two weeks. This will be Brock Purdy's first road start, and it is in one of the most hostile environments in the NFL, so expect some regression from him.
✅ Geno Smith is an all-time great at covering the spread in primetime games. He is 7-1 against the spread in primetime games during the regular season in his career.
✅ Deebo Samuel is hurt and will miss this game for the 49ers. That will make the Niners offense way more predictable to the detriment of San Francisco.

TeamsSan Francisco 49ers vs. Seattle Seahawks
WhenThursday, December 15, 2022 at 8:15 PM ET
VenueLumen Field, Seattle, WA
Betting PickSeahawks +3.5 over 49ers

Looking for more NFL picks for this week? Get a complete preview of NFL Week 15 action at ATS.io.

Best Seahawks vs 49ers Sportsbook Promo

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San Francisco 49ers

The San Francisco 49ers are one of the hottest teams in the NFL right now, as they are in the middle of a six-game winning streak coming into this matchup. They have not missed a beat despite losing their starting quarterback Trey Lance early in the season, and their backup quarterback Jimmy Garoppolo just a couple of weeks ago. Now, they go into battle with Brock Purdy as their starting quarterback, as he gets set for his first road start as a professional football player.

The combination of Purdy being on the road for the first time and the Niners being without Deebo Samuel could really hurt them in this game. Fortunately, they still have Christian McCaffrey to rely on offensively and the best defense in the NFL to rely on when they do not have the ball. San Francisco comes into this game with the top scoring defense in the NFL, and that alone could be enough for them to overcome the adversity they are facing.

Seattle Seahawks

The Seattle Seahawks come into this game not quite in a must-win situation, but very close to it. They trail the San Francisco 49ers by two games in the NFC West standings, and they are just outside of the top-seven in the NFC and on the outside of the Wild Card spots coming into this week. With either the Washington Commanders or New York Giants set to lose this week (barring another tie between them), the Seahawks could move into the top-seven with a win here.

For the Seahawks, the question coming into this game will be their defense against a Niners team that has played well offensively with Brock Purdy at quarterback. Seattle has given up 30 or more points in two of their last three games, including last week against a Panthers team with the lackluster Sam Darnold playing the role of quarterback for them. If the Seahawks defense does not tighten up here, they could be in for a devastating loss for their playoff hopes.

Jay
Jay Sanin
Jay Sanin is a sports writer and broadcaster from Albany, NY. He has covered sports betting and the gambling industry since 2013.