Chargers vs Colts Sportsbook Promos & Prediction 12/26/22

Last updated December 24, 2022

1:15 AM ET Dec 27
Chargers vs Colts
Colts +5

Monday Night Football will close out the NFL Week 16 schedule with two teams in very different spots heading into the season's few weeks. The Los Angeles Chargers and Indianapolis Colts will battle in Indianapolis in a game with high stakes for one side and quarterback intrigue for the other.

Here, we give our NFL betting picks for Chargers vs Colts and look at the top sports betting promotions for this contest.

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The Pick: Colts +5
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Why bet on the Colts:

✅ Indianapolis is going with Nick Foles at quarterback over Matt Ryan this week, which should give their offense a boost
✅ The Colts are 10th in the NFL against the pass and should be able to slow Justin Herbert down
✅ The Chargers have won just one road game by more than five points this year, and that was against a Texans team that is the worst in the NFL

TeamsLos Angeles Chargers vs Indianapolis Colts
WhenMonday, December 26, 2022 at 8:15 PM ET
VenueLucas Oil Stadium, Indianapolis, IN
Betting PickColts +5 over Chargers

Get NFL picks for all of the Week 16 action by visiting our friends at!

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Los Angeles Chargers

The Los Angeles Chargers are coming off of a dramatic win over the Tennessee Titans last week to move to 8-6 on the season. Coming into this week's games, the Chargers are sixth in the AFC standings, and are closing in on a playoff spot. Here, they will test themselves against a tough Colts team that is shaking things up at the quarterback position.

In this game, Justin Herbert will be tested once again. He threw for 313 yards against the Titans last week, but the Chargers managed to score just two touchdowns. Herbert will need to be more clinical when in scoring range to help his team win this contest.

Indianapolis Colts

The Indianapolis Colts are eliminated from playoff contention after last week's miraculous loss to the Minnesota Vikings. Indianapolis led that game 33-0 at halftime, but were outscored 39-3 to finish the game, losing 39-36 in overtime. Here, the Colts will look to rebound, and will turn to a Super Bowl winning quarterback in hopes of doing that.

Nick Foles will get the start at quarterback for the Colts, replacing Matt Ryan under center. Foles led the Eagles to a postseason run that ended in a Super Bowl victory over the New England Patriots. But that was a long time ago, and it will be interesting to see how he performs in his first game since December of 2021.

Jay Sanin
Jay Sanin is a sports writer and broadcaster from Albany, NY. He has covered sports betting and the gambling industry since 2013.